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Home Remedies

Home remedies for fever

Now a days many of them keep getting ill be it because of not taking proper care of themselves or not being hygiene. Fever is one such disease that may occur any at times. This illness is ignored most of time but everyone should make sure so take precautions and not avoid it where you can get more ill. Fever can be a symptom of many health problems be it a flu or only a viral fever. Here are some of the home remedies for fever that can follow if you have a mild fever or even you want to control the fever which is increasing on a daily basis.

Baby Fever: How to Care for a Sick Baby

Stay Hydrated

The most imported step is to stay hydrated. Make sure you have lot and lot of water or other fluids so that you don’t go through dehydration. Drinking lot of fluids will help you give good amount of energy and not let you feel dizzy.

Warm water bath

If you are going through a viral or fever always have a Luke warm water bath so that the high temperature in your body can reduce a bit. Also, make sure the person should bath with complete cold water as he may get chills and there may be a rise in temperature.

Damp Cloth

This home remedy is being practiced from ages and is still practiced by everyone. Once the person is resting or sleeping, put a damp cloth on his forehead that is dipped in cold water. Follow this process in every 3 or 5 minutes which should go on until the temperature comes down a little.

Light Clothes

It is every important the person should make sure wear light and free clothes so that he can feel relaxed and not feel heavy. Make sure to not wear woolen clothes or packed clothes. Also avoid to use heavy blankets so that you don’t generate heat in your body.

Take a lot of rest

This is the most important step to follow. Make sure you take lot and lot of rest until you are fully recovered. If you move around u may catch more fever and also cold and cough because of too much exposure.

These are some of the home remedies for fever that you can consider to lower the temperature or if you are suffering from viral fever. We hope you have liked this post and stay healthy.

Thank You!

Categories
Pharmacy

Dedication to science drives a 20-year relationship between an information expert and a distinguished researcher

With about 600 articles published in major dermatology
journals, almost 40 books authored, 70 chapters in various books, and a h-index
of 49, Dr. Robert Baran is one of the most knowledgeable dermatologists in the
world. He began publishing more than 67 years ago, is invited to many
international conferences every year, and his specialty is nails.

He’s the one to ask about nail diseases and their therapies, and is one of the more active researchers in this field (Scopus mentions 7200+ citations and 380+ co-authors). He has membership in many societies (not the least of which is the American Academy of Dermatology as Honorary Member), and serves on many editorial or advisory boards.

Literature to the rescue

Dr. Baran is also a practitioner and leads the Nail Diseases
Center in Cannes, France, balancing his life between research and patient care.
But he has a challenge: he has no access to research facilities, such as a
general hospital. How does he manage this issue? Literature is the answer. His
office, where he writes his publications, is a real library, devoted to
dermatology, with thousands of references: articles, reviews, pre-prints,
books, abstracts of congresses, notes, and so on.

Delivering the nail bibliography

For decades, Dr. Baran has relied on information
professionals to survey what happens in the field of several subjects that he
is interested in. And I’m one of them. I have been helping Dr. Baran for almost
20 years, ever since I was a scientific information expert at a pharmaceutical
company, devoted in dermatology. Now I serve as a customer consultant at
Elsevier.

Every month, I provide Dr. Baran with the ‘nail
bibliography’, a survey of the biomedical literature, focused on the nail and
its diseases. Dr. Baran wants it to be quite detailed, to be sure we do not
miss any important papers (clinical trials, opinions, new cases, etc.). To meet
his needs, I have created a broad search strategy that covers Dr. Baran’s
favorite subjects, such as onychomycosis. He receives an alert, every month,
and then selects the relevant references.

How Embase helps

In this effort, I have always used Embase and MEDLINE, and,
for 10 years now, Embase.com. This is for several reasons, the first one being
the coverage. Dr. Baran needs a deep understanding and coverage of the
literature. He has an impressive comprehensive memory and understanding of the
literature in dermatology, and is still eager to learn more and more—that is
how he produces such a high-level work.

That is why combining the coverage of MEDLINE and Embase is mandatory. On average, in Embase.com, the unique Embase content represents about 28% of the database, MEDLINE stands for 28%, and 44% of the content is covered by both databases.

For the ‘nail bibliography’, 34% of the references are from the unique Embase content, which is meaningfully more than the expected average. That is why covering Embase and MEDLINE is valuable. Embase.com allows us to address both with a single request, using the Embase vocabulary, the Emtree thesaurus. This is another reason why I utilize Embase.com: it enables me to create a single search strategy that combines Emtree terms and free text words to broadly cover the subject. Emtree terms focus on very specific concepts, such as onycholysis or paronychia. Free text words help to cover the records that were very recently added to Embase.com and that are still in process.

Getting automatic alerts

Once the search strategy is designed, Embase.com helps to
automatically manage email alerts. So, each month, I receive an email, and then
I log into Embase.com to screen the bibliography—a task that is easier with the
clipboard and export feature. The search strategy can be modified or improved
at any time, according to the needs of Dr. Baran.

This emblematic example illustrates the usefulness of a tool
with a very broad content and advanced search functions. In the hands of a
scientific information expert, it makes it possible to best meet the needs of
the most demanding researchers.

Check out Embase.com now for yourself, or contact me if you want to know more about Embase and how it can help your research.

Categories
Pharmacy

Medicines Discovery Catapult Nurture Next Generation Drug Discovery Researchers

Medicines Discovery Catapult (MDC) have welcomed a cohort of MRC-funded PhD students as part of a training, talent and skills agenda to help develop the next generation of drug discovery researchers.

Charlotte Criscuolo, University of Manchester; Rebecca Kelly, University of Liverpool; Michael Eyres, University of Oxford; and Tim Muntslag, University of Southampton have joined MDC to work on 4-6-month neuroscience and biomarker research projects.

The projects provide the next generation of innovative scientists with key training and exposure to industrial R&D, whilst increasing MDC’s capacity to carry out novel science in areas of benefit to the UK’s drug discovery industry.

Dr Nicola Heron MBA, Head of Collaborative R&D, Medicines Discovery Catapult and External Advisory Board Member, MRC DiMeN Partnership, said:

“Fostering the next generation of innovative scientists and budding entrepreneurs is crucial for the future of drug discovery. By hosting these students at MDC, we are helping to develop their commercial skills and industrial knowledge, plus the generic skills all researchers require to succeed – communication, time management, teamwork and critical thinking. The students also bring novel scientific approaches to MDC that are of potential benefit to the UK’s drug discovery community. The advantages of this Doctoral Training Programme are genuinely reciprocal, and it is a pleasure for MDC to be involved.”

Dr Martin Main, Head of Molecular Technologies, Medicines Discovery Catapult, said:

“Drug Discovery, like any scientific field, is constantly evolving. Hosting these students at MDC is invaluable. It gives us the opportunity to not only to pass on the scientific skills and knowledge my colleagues and I have developed through years of experience, but to also learn from these early career researchers who are incubators of novel science. It is a real privilege to play a part in setting them up for future scientific success through this Doctoral Training Programme.”

The positions were advertised through the Discovery Medicine North (DiMeN) Partnerships Doctoral Training Programme (DTP), and across the wider network of MRC-funded university DTPs, demonstrating a collaborative academic approach to nurturing talent and providing development opportunities to researchers throughout the UK.

The DiMeN partnership is made up of partner institutions including the Universities of Leeds, Liverpool, Newcastle and Sheffield, and aims to train the next generation of researchers to tackle the major health problems facing the population.

The partnership provides up to 30 fully funded studentships across the partnership per year, focussing on the complementary themes of:

  • Genetic Influences on Health
  • Ageing and Disease
  • Bioinformatics and Personalised Medicine

For more information on DiMeN and the DTP please visit: https://www.dimen.org.uk/

The post Medicines Discovery Catapult Nurture Next Generation Drug Discovery Researchers appeared first on .

Categories
Home Remedies

Home Remedies for Cough

In day to day life with this busy schedule it is little difficult to take care of yourself especially about the toddlers. Kids and babies may get cough or cold at any time as they are not much attentive on their health as they are always in playground and dust plus they eat unhygienic food which may lead to many other illnesses. One of the most common one is cough which keeps on occurring. Rushing to doctor all the time is little difficult so there are some natural home remedies cough toddler and kids that can be used and are effective too.

Image result for Home Remedies for Cough

Honey

Honey is the most effective natural home remedies that can be given to the kids more than 1 year and above. Honey is one such liquid that is also loved by kids as it is very sweet and taste goods. This home remedy is highly recommended as it is an easy intake by the kids and also the best one.

Hot Fluids

Hot fluids are also one of the best home remedies cough toddler that can be used to clear the cough and get rid of itching. Drinking hot fluids like warm water or soups can help in reducing the thickness of the mucus and also it will help you stay hydrated.

Salt water gargle

Salt water gargle is also a very popular home remedy that is been used from ages to clear the itching caused due to dry cough. Here you have to mix salt with warm water and let your kid gargle and throw out the solution. This remedy is only recommended for older kids.

Chest Rub

This is also one of the home remedies that is used from ages by all our elders to clear the blogs of your nose to breathe in peacefully. But it also said that rubbing it on chest and increase mucus so it is recommended to apply it only near the nostrils.

These are some of the nature and best home remedies cough toddler that can be used to get kid of the irritation of cough and cold quickly with easy techniques. Make sure to consult a doctor if the kids have lot of cough and cold and can’t be controlled by these natural home remedies. We think you have got all the information you were looking for and found this article helpful. Do share your reviews on the same and let us know if you have any doubts or quires.

Stay Connected and Thank You for Visiting.

Categories
Pharmacy

CHMP turns down Lilly’s Emgality for cluster headache

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An EMA advisory panel has rejected expanding the use of Eli Lilly’s Emgality to include prevention of episodic cluster headaches.

The Committee for Medicinal Products for Human Use (CHMP) said the single 106-patient study filed by Lilly to support the new marketing application for Emgality (galcanezumab) “did not show clearly that Emgality is effective for preventing attacks” in people with cluster headaches.

The CGRP inhibitor has been approved in the US and Europe for chronic migraine prevention since 2018, and was cleared by the FDA for the cluster headache indication last June, becoming the first drug for this indication in the US.

Cluster headaches are distinct from migraine and less common, but are considered to be much harder to treat. They are characterised by severe pain, typically on one side of the head and around an eye, with attacks occurring during ‘cluster periods’ which can last weeks to months, notes the CHMP.

Lilly’s clinical trial – called GCAL – showed that over a three-week study period, patients given Emgality experienced 8.7 fewer weekly cluster headache attacks than they did at enrolment, compared to 5.2 fewer attacks for the placebo group.

That difference only just scraped above the threshold for statistical significance, however and the FDA is thought to have allowed its approval because of the lack of effective treatments for cluster headache, plus supportive secondary results in the trial such as the proportion of patients seeing a 50% or greater reduction in weekly attacks.

The CHMP has clearly taken a tougher line, and its negative opinion means patients in Europe will have to wait longer for a treatment option.

To give an indication of just how debilitating the condition can be, subjects in Lilly’s trial averaged more than 17 cluster headache attacks per week during the baseline period, equivalent to 2-3 every day. Attacks typically last between 15 to 180 minutes.

The CHMP’s verdict was also a blow commercially for Lilly, which was third to market after rival injectable CGRP inhibitors Aimovig (erenumab) from Amgen and Novartis – the market leader – and Ajovy (fremanezumab) from Teva.

Being the first CGRP drug to get a claim for cluster headache on the label in the US is viewed as a way for Lilly to carve out its own niche market, particularly as neither Aimovig nor Ajovy remains in development for this indication.

There is more competition in play for Emgality from Lundbeck’s new intravenous CGRP drug Vyepti (eptinezumab), which requires less frequent dosing of Emgality as well as Aimovig and Ajovy, but has to be given intravenously in a clinic rather than by subcutaneous self-injection.

Amgen reported $306 million from US sales of Aimovig last year, while ex-US licensee Novartis doesn’t break out its sales of the drug. Emgality leapfrogged second-to-market Ajovy last year, making $163 million compared to $96 million for Teva’s drug, thanks in part to the cluster headache approval.

GlobalData said last week – ahead of the cluster headache rejection – that it expects Aimovig and Emgality to lead the migraine prevention market in 2025 with sales of $1.8 billion and $1.7 billion respectively, with Vyepti making around $566 million in that year.

Meanwhile, there are challenges elsewhere in Lilly’s migraine franchise too, with two new orally-active CGRP blockers for acute migraine treatment – Allergan’s Ubrelvy (ubrogepant) and Biohaven’s just-approved Nurtec ODT (rimegepant) – expected to exert pressure on Lilly’s acute therapy Reyvow (lasmiditan).

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A first-in-class 5-HT1F receptor agonist, Reyvow was cleared by the FDA in October but only launched a few weeks ago – at a price of $640 for eight pills – because it had to wait for scheduling by the US Drug Enforcement Administration (DEA).

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Pharmacy

FDA report shows 2019 was a strong year for innovation

Source: FDA.gov

On January 2, 2020, the FDA released the CDER annual report, stating that 2019 was “another strong year for innovation and advances.” The FDA cleared 48 new drugs for market, making it the second most productive year in the last decade (2018 approved 59 drugs). But given the fact that the total number of submissions have gone down, and that the American government was shut down for a lengthy period at the beginning of the year, the FDA delivered an impressive result in 2019.

I’d like to share some of my personal thoughts
after reading this report. Here are a few notable highlights and my takeaways:

1. 21 of CDER’s 48 novel drug approvals, or 44%, were orphan drugs

What does that tell us?

* As Janet Woodcock, director of the FDA’s Center for Drug Evaluation and Research, puts it, “New drug therapies for patients suffering from rare diseases are often among the most important approvals. Patients with rare diseases frequently have few or no drugs available to treat their condition — and for them, approvals of so-called “orphan” drugs can mean new hope for an enhanced quality of life, and in some cases, survival.”

* Patient unmet needs and market value merges where the pharmaceutical companies pay attention and take practical approaches. One of the most promising avenues that big pharmas can take is to partner with non-profits focused on particular unmet needs, and to collaborate with small biotech companies that are specializing in tackling unmet needs. One such example is Beacon Discovery, which has partnered with several leading companies, focusing on helping them with early-stage research and discovery.

If 2019 was a good year for orphan drugs, 2020 is already getting off to a great start. In Q1, three more possible orphan drugs to be on the look-out for include: Oxbryta, the first treatment to address the root cause of sickle cell disease (SCD); Adakveo, an injectable treatment for SCD patients who suffer from vaso-occlusive crises (VOC); and Givlaari, a drug to treat the blood disorder acute hepatic porphyria (AHP). Learn more about these drugs here.

2. Innovative
new therapies

Some of these new drugs in development are built
on very exciting new innovations:

* The above-mentioned Givlaari is based on RNA interference (RNAi), a technique that silences abnormal gene expression. As BioSpace reports, Givlaari is only the second drug to be approved leveraging RNAi.

* The cancer drug Rozlytrek, for pan-tumor use, marks only the third time that the FDA has “cleared a cancer drug to treat tumors based on a specific genetic signature rather than by location in the body,” explains BioPharmaDive.

As evidenced by the emergence of innovative drugs like these, my personal opinion is that we are truly transitioning into the era of precision medicine and personalized medicine, when more and more oncology drugs are being developed based on the use of biomarkers and targeted delivery of medicine.

3. 10 new biosimilars

Biosimilars, which are drugs that are very
similar to already-approved biologics, had a busy regulatory year in 2019, with
many new approvals and new guidance documents published.

There were 10 biosimilar approvals covering
indications for numerous conditions, such as rheumatoid arthritis, plaque
psoriasis, breast cancer, metastatic stomach cancer, metastatic colorectal
cancer, non-squamous non-small cell lung cancer, glioblastoma, metastatic renal
cell carcinoma, cervical cancer, B-cell non-Hodgkin’s lymphoma, chronic
lymphocytic leukemia, granulomatosis with polyangiitis, and microscopic
polyangiitis.

“Biosimilars have great potential for both patients and the entire health care system. As patents and exclusivity protections for biologics expire in the United States, we can expect many more biosimilars to be submitted for approval. More products on the market means greater competition that can lead to increased access to therapies and lower costs to patients.”
– Janet Woodcock

4. The first-ever FDA novel approval drug from a Chinese pharmaceutical company

November 14, 2019  was a clear milestone for Chinese pharmaceutical companies, as it was then that Brukinsa from BeiGene received FDA approval for the very first novel therapy from China in history. Regulatory reform in China has enhanced innovative drug discovery and clinical development, encouraging innovation and speeding patient access to new drugs.

Studies showed that BeiGene’s drug has real promise. “The FDA’s decision is largely based on tumor shrinkage data from a phase 2 trial in 86 Chinese patients,” reports FiercePharma. “In that single-arm study, Brukinsa triggered an overall response rate of 84% with a median duration of response of 19.5 months. Some 59% of patients saw a complete response, meaning their cancers were undetectable after treatment.”

A mission to work together

To quote Janet Woodcock once more: “CDER’s mission goes well beyond
critically reviewing the safety and efficacy of drug applications we receive
from industry … We are working to develop more innovative and efficient
approaches for the development and study of the drug therapies that will emerge
from these technological advances.”

I believe this is also the dream and the
mission of most people working in the pharmaceutical industry: to work
collaboratively with partners across academia, industry, patients, caregivers
and regulators to provide true benefits for patients. We at Elsevier Life
Sciences solutions all share that same mission.

If you are interested in finding out more about collaborations to support drug discovery and development, please read more on our website.

Categories
Home Remedies

Acne Home Remedies Divided by Skin Type

“Acne Home Remedies For Fair Skin”

Mixing Baking Soda W/ Water: The most generic, though effective of acne home remedies. The baking soda uses an all-natural alcohol free method of drying up the excess sebum under the skin. Mix a cup of baking soda with a little water until it becomes a paste, apply to the infected spot (not the whole face). Leave on for 15 minutes and gently wipe off. Feel fabulous.

Get Smelly, Mush Up Some Acne Home Remedies w/ Garlic: Ready to wreak? The very effective method is a powerhouse in acne treatment. Peel back a clove of garlic, chop it up till its a mush, then apply to whole face for 20 minutes. Remember to wash it off, unless you like the smell of garlic.

Apple Cider Vinegar and Water Solution: Ouch! This one might leave a little sting if your not careful. If your skin is sensitive be sure to dilute the vinegar with water appropriately. This is one of my favorite acne home remedies because it’s so strong and gets to work pretty darn fast. Apple cider vinegar is a strong astringent packed with skin protecting vitamins. To use, mix with water and apply with a cotton swab. Don’t rinse.

The Orange Peel Facial: Time to smell daringly citric! It’s the most fruity of our acne home remedies. Peel the orange, flatten it with a tenderizing utensil or other blunt object (surprisingly, even a hammer works) and apply the peel to your acne area. (You can even go as far as taping it on your face). Leave on for 20 minutes and remove. Be careful not to snatch the tape off too fast. Ouch!

Combining Aspirin and Water: Headache pills for the face? I’ve never tried this one myself but I’m hearing it’s very powerful so I wouldn’t over-do it. To use, crush an aspirin and add a little water until it becomes a paste. Apply the paste to a single pimple spot only and let it sit overnight. Rinse at wake.

Tomato Juices Work Wonders: Tomato juice anyone? For this home remedy take a tomato and place it in the blender or chop and squeeze. If you decide to use a blender for your acne home remedies, make sure you clean it thoroughly beforehand. This way, you wouldn’t have any leftover residues from last weeks chocolate shake sitting on your face. Apply the juices for an hour then rinse off. But be warned, frequent use of tomato juice will dry out your skin. Try other acne home remedies from time to time.

Green Tea Ice Cube: Got spare green tea lying around? If you do, then you got one acne’s greatest home remedies. Freeze green tea into an ice cube and apply to a specific spot. Use until swelling decreases or it melts away.

The Lemony Rose Water Supreme Combo: Combining these 2 deadly acne killers will definitely thwart the competition (no pun intended). To use, mix a half cup of rosewater with a quarter of lemon juice and apply to infected area. The rosewater will repair damaged skin and the astringent will suck up excess sebum. The ideal acne fighting tag-team.

Break an Egg, Clear a Face: Egg whites are the perfect facial cleansers and make pretty strong acne home remedies. To keep the acne away, break an egg, separate the white from the yolk, apply to whole face and feel your skin tighten. Wash away in an hour and feel refreshed! Or just really eggy.

Green Tea Ice Cube: For this method, you get to eat the majority of the strawberry, and the best part is strawberries are really good for you! Eat the berry part, save the crown part and apply to infected area. After 20 minutes rinse and relax. Like my orange peel strategy, you can feel free to use tape.

Potato Slice Plain and Simple: Potato slices work wonders. Slice one, hold it on your face for as long as you want and enjoy. You can leave it on all day if you wish. Cant have too many potato’s. Simple acne home remedies personified!

“Acne Home Remedies For Dryer Skins”

Stir up some avocado and honey: My best choice for a homemade moisturizing mix. Mash up some avocado, add some honey to make a paste, and apply to infected area. Do not overdo the honey. To much honey will lead to clogged pores. Apply to face and wash off in 20 minutes. Avoid rubbing in.

Olive Oil Absorption: As with all skin moisturizing agents be careful of applying too much and doing more harm than good. Take a table-spoon, dilute with a very little bit of water, and apply to infected area. Let sit for 20 minutes and pat dry. Simple acne home remedies at it’s finest.

Categories
Home Remedies

3 Major Factors To Quality Arthritis Home Remedies

Determining the Quality

Have you tried to sort through the masses of alleged arthritis home remedies on the internet? Have you ever wondered what makes a remedy effective and how we can distinguish the good ones from the bad? Well, it all boils down to a few key factors that we can apply to any new remedy we would like to try.

At first glance, there are a few questions we need to ask ourselves when trying out any new arthritis home remedies. Does it reduce inflammation? And if so, how does it? Does it provide nutrients to aid in the rebuilding process of lost connective tissue due to arthritis? Does it prevent arthritis from occurring in other joints of my body? Or could it help me lose weight to prevent the extra strain on weight barring joints affected by arthritis (if that is a factor)?

There are a few ways your arthritis home remedies can reduce inflammation in your body. Creating alkalinity to reduce inflammation is a good start. Alkaline remedies can also have a number of other amazing health benefits.

Alkalizing Arthritis Home Remedies

When we consume alkaline foods, drinks or other remedies, we create an alkaline pH balance within our body. When our body is in an alkaline state, it is much harder for it to create inflammation, thus we can reduce our joint pain and the progression of the disease simply by consuming foods or drinks on the high side of the pH scale. Alkaline arthritis home remedies must have a pH higher than seven, or contain substances that create a pH higher than seven.

The majority of easy to make arthritis home remedies are drink concoctions made up of a combination of alkalizing anti-oxidants. The most common remedies I see recommended are simple drinks with added alkaline vitamins such as a glass of plain water with a slice of lemon or lime.

You may be thinking… Aren’t lemons and limes acidic? Yes, they are acidic by nature, but they contain vitamins such as vitamin C that has the ability to create an alkalizing effect on the body once absorbed. The same thing can be said for the majority of citrus fruits.

These two simple remedies serve as a triple threat to arthritis. They alkaline, hydrate and detoxify, which brings me to another key factor to creating your own arthritis home remedies.

Anti-oxidants for Arthritis Home Remedies

There is a growing theory that low amounts of dietary anti-oxidants can cause and contribute to the development and progression of arthritis. It makes sense when you understand the oxidative damage that can be caused by a low intake of anti-oxidants. Luckily, incorporating anti-oxidant rich foods can drastically reduce oxidative damage on our body and be easy and delicious.

There are many drinks and snacks we can whip up at home that can provide us with a hefty dose of anti-oxidants. The majority of vitamins are detoxifying on the body; as long as you are intaking naturally sourced vitamins and not synthetic vitamins.

This isn’t to say that all vitamin supplements are synthetic. Some are natural and some are synthetic. If you can’t tell the difference, just make sure to buy your vitamins from a health food store and not a drug store.

Berry or vegetable mixes are amongst my favorite arthritis home remedies. I know that right off the bat these don’t sounds overly interesting, but as I said, a good arthritis home remedy can be as simple as a glass of water with lemon or lime.

Berries can provide a strong dose of anti-oxidants with little effort. You can whip up a berry smoothie with only a handful of blueberries, three or so strawberries and maybe even a half a banana for a bit more flavor.

This one berry smoothie can provide three out of the five keys factors to great arthritis home remedies.